Ireland pair James Ryan and Garry Ringrose have been ruled out of Saturday’s Six Nations clash with England in Dublin, the Irish Rugby Football Union has announced.

Vice-captain Ryan was forced off for a head injury assessment during Sunday’s 27-24 win over Scotland, while centre Ringrose sustained an ankle injury in that game.

Finlay Bealham will remain with Andy Farrell’s squad having provided additional cover at Murrayfield but fellow prop Tom O’Toole will stay with Ulster after picking up a knock at the end of last week.

Flanker Peter O’Mahony will return from a three-match ban for the visit of Eddie Jones’ men.

Ireland have not defeated England since 2018 when they emerged with a 24-15 victory at Twickenham to secure the Grand Slam.

Ireland’s wider squad for England game

Forwards: Ryan Baird, Finlay Bealham, Tadhg Beirne, Ed Byrne, Jack Conan, Will Connors, Ultan Dillane, Tadhg Furlong, Cian Healy, Dave Heffernan, Iain Henderson, Rob Herring, Ronan Kelleher, Dave Kilcoyne, Peter O’Mahony, Andrew Porter, Rhys Ruddock, CJ Stander, Josh van der Flier

Backs: Bundee Aki, Billy Burns, Ross Byrne, Craig Casey, Andrew Conway, Keith Earls, Chris Farrell, Jamison Gibson Park, Robbie Henshaw, Hugo Keenan, Jordan Larmour, James Lowe, Stuart McCloskey, Conor Murray, Jonathan Sexton, Jacob Stockdale