Chris Farrell will make his first Championship start, partnering Bundee Aki in the centre, while Rob Kearney is named at full-back in the middle of wings Keith Earls and Jacob Stockdale.
The front-row remains the same as last week as captain Rory Best is joined by Cian Healy and Tadhg Furlong. However due to Devin Toner’s injury, Quinn Roux comes in at lock to partner James Ryan.
Sean O’Brien and Jack Conan are introduced to the back-row with Peter O’Mahony retained on the blindside flank as Ireland look to bounce back from the loss to England.
The replacements named for the weekend are Sean Cronin, Dave Kilcoyne, Andrew Porter, Ultan Dillane, Josh van der Flier, John Cooney, Joey Carbery and Jordan Larmour.
Ireland: 15 Rob Kearney, 14 Keith Earls, 13 Chris Farrell, 12 Bundee Aki, 11 Jacob Stockdale, 10 Johnny Sexton, 9 Conor Murray, 8 Jack Conan, 7 Sean O’Brien, 6 Peter O’Mahony, 5 Quinn Roux, 4 James Ryan, 3 Tadhg Furlong, 2 Rory Best (c), 1 Cian Healy
Replacements: 16 Sean Cronin, 17 Dave Kilcoyne, 18 Andrew Porter, 19 Ultan Dillane, 20 Josh van der Flier, 21 John Cooney, 22 Joey Carbery, 23 Jordan Larmour